Protein Structure and Function

Goal:
Construct an argument for how the structure of a protein is important to its function.

Agenda:
Warmup
Protein Structure and Function
Protein Project

Download:
Protein Structure and Function Worksheet (PDF / Google Doc) - Open in Notability
Protein Project - Make a copy in Google Docs and share with me

Warmup
Finish your abstract in yesterday's journal entry.
1-2 introduction sentences that explain topic, purpose, and research question(s).
1-2 sentences describing your research methods.
1-2 sentences describing the results / findings.
1-2 sentences containing your conclusions and recommendations.

Protein Structure and Function
Follow the directions in the worksheet to complete the activity. Turn it in here.

Protein Project
Choose a molecule to research from the Protein Data Bank's "Molecule of the Month" for your protein project. Submit your choice here.

Catalase Lab

Goal:
Make inferences from lab data about the amount of enzymes present in different organisms.

Agenda:
Warmup
Catalase Lab
Abstract

Download:
Enzyme Lab - Open in Notability

Warmup
Create a new journal entry entitled "Catalase Lab."
Copy down WHAT we are learning today.
Complete the Socrative Quiz.

Catalase Lab
1. Answer the pre-lab questions (page 1) of the catalase lab document.
2. Complete the catalase lab.
3. Answer the post-lab questions.

Abstract
Write abstract in journal. Use the outline below as a guideline.
1-2 introduction sentences that explain topic, purpose, and research question(s).
1-2 sentences describing your research methods.
1-2 sentences describing the results / findings.
1-2 sentences containing your conclusions and recommendations.

Enzymes

Goal:
Explain how the structure of an enzyme allows it to speed up the rate of chemical reactions.

Agenda:
Notes + Socrative
Practice

Download:
Enzymes and their Function - Open in Notability

Warmup
Create a new journal entry entitled "Enzymes."
Copy down WHAT we are learning today.

Notes + Socrative
Log in to Socrative. This is a long lecture and I will be asking you to stop and answer questions throughout on Socrative.
Take notes on these slides.


Practice
Complete the "Enzymes and their Function" worksheet. Then submit your completed worksheet to this Google Form.

Active Sites

Goal:
Create a model to explain the role of shape and chemical properties of amino acid R-groups in a protein’s active site.

Agenda:
Warmup
How do we smell?
Model Olfactory Receptors

Download:
The Role of the Active Site - This is a reading. Open in your preferred app for annotation (Notability or Google Docs)

Warmup
Create a new journal entry entitled "Active Sites."
Copy down WHAT we are learning today.
Log in to Socrative.

How do we smell?

Watch TedEd video “How do we smell?”

In your journal, write a hypothesis for the question: How do our olfactory receptors distinguish between different smells?
Read “The Role of the Active Site” and revise your hypothesis.

Model Olfactory Receptors
1. Work in pairs to create a model of olfactory receptors that meet the shape and chemical property requirements of the provided “smell molecules” (puzzle pieces).
2. Using your model, create a stop motion video to explain how the olfactory receptors work using the terms: functional groups, receptor, active site, chemical properties (of amino acid R-group).

Protein Folding

Goal:

Model how the intermolecular forces between amino acids cause proteins to fold in predictable shapes. Hypothesize how the structure of the folded protein might contribute to its function.

Agenda:
Warmup
ACT Reading
Protein Folding Activity
Revised CER

Warmup
Create a new journal entry entitled "Protein Folding."
Copy down WHAT we are learning today.
Write a CER to answer the question: What structural features of a polypeptide most contribute to protein folding? Explain.

ACT Reading
Read and answer the questions to this ACT practice passage.

Protein Folding Activity
Follow the directions in this document to complete the protein folding activity. Then answer the following questions in your science journal:

1. Take a picture of your folded protein and explain how you arrived at this shape.  Use the words secondary and tertiary and include a discussion of R-group properties (such as charge etc.)
2. What step needs to occur next before the protein can be considered “complete”?
3. Imagine for a moment your protein has a “job.”  Be creative and explain how it’s shape might help it do it’s job.  Refer back to the 9 types of proteins  for ideas.

Revised CER
Use what you learned in the protein folding activity and the ACT reading to revise your CER from the beginning of class.